組蛋白乙酰轉(zhuǎn)移酶抗體
規(guī)格：1mg/1ml
英文名： MGEA5
別名： Bifunctional protein NCOAT; Glycoside hydrolase O-GlcNAcase; HAT; HEXC; Hexosaminidase C; Histone acetyltransferase; KIAA0679; MEA5; Meningioma expressed antigen 5; Meningioma-expressed antigen 5; MGE
分子量： 103kDa
儲(chǔ)存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類(lèi)型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from hu MGEA5
交叉反應(yīng)：Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Sheep,
細(xì)胞定位：細(xì)胞核 細(xì)胞漿
組蛋白乙酰轉(zhuǎn)移酶抗體產(chǎn)品介紹：background: The dynamic modification of cytoplasmic and nuclear proteins by O-linked N-acetylglucosamine (O-GlcNAc) addition and removal on serine and threonine residues is catalyzed by OGT (MIM 300255), which adds O-GlcNAc, and MGEA5, a glycosidase that removes O-GlcNAc modifications (Gao et al., 2001 [PubMed 11148210]).[supplied by OMIM, Mar 2008]. Function: Cleaves GlcNAc but not GalNAc from glycopeptides. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc. Possesses hyaluronidase activity. Acetylates 'Lys-8' of histone H4 and 'Lys-14' of histone H3 (By similarity). Subunit:組蛋白乙酰轉(zhuǎn)移酶抗體 Monomer. Binds both acetylated and unacetylated histone H4 tail but acetylation on 'Lys-8' of histone 組蛋白乙酰轉(zhuǎn)移酶抗體H4 abolishes binding (By similarity). Subcellular Location: Isoform 3: Nucleus. Isoform 1: Cytoplasm. Tissue Specificity: Ubiquitous. Shows highest expression in the brain, placenta and pancreas. [PTM] Proteolytically cleaved by caspase-3. Database links: UniProtKB/Swiss-Prot: O60502.2 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
組蛋白乙酰轉(zhuǎn)移酶抗體產(chǎn)品應(yīng)用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領(lǐng)域：腫瘤 細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 腫瘤細(xì)胞生物標(biāo)志物 表觀遺傳學(xué)
儲(chǔ)存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
來(lái)源： Rabbit
外觀： Lyophilized or Liquid