谷氧還蛋白/巰基轉(zhuǎn)移酶抗體
規(guī)格：1mg/1ml
英文名： Glutaredoxin 1
別名： Glrx; Glrx1; GLRX1_HUMAN; Glutaredoxin; Glutaredoxin-1; Glutaredoxin1; Grx 1; Grx; Grx1; Thioltransferase 1; Thioltransferase; Thioltransferase-1; Thioltransferase1; TTase; TTase 1; TTase-1; TTase1.
分子量： 12kDa
儲(chǔ)存液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glyce
克隆類型：Polyclonal
亞型：IgG
純化方法：affinity purified by Protein A
**原：KLH conjugated synthetic peptide derived from human Glutared
交叉反應(yīng)：Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
細(xì)胞定位：細(xì)胞漿
谷氧還蛋白/巰基轉(zhuǎn)移酶抗體產(chǎn)品介紹：background: This gene encodes a member of the glutaredoxin family. The encoded protein is a cytoplasmic enzyme catalyzing the reversible reduction of glutathione-protein mixed disulfides. This enzyme highly contributes to the antioxidant defense system. It is crucial for several signalling pathways by controlling the S-glutathionylation status of signalling mediators. It is involved in beta-amyloid toxicity and Alzheimer's disease. Multiple alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2011]. Function: Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. Subcellular Location: Cytoplasm. Similarity: Belongs to the glutaredoxin family. Contains 1 glutaredoxin domain. Gene ID: 2745 Database links: Entrez Gene: 515416 Cow Entrez Gene: 2745 Human Entrez Gene: 93692 Mouse Entrez Gene: 397463 Pig Entrez Gene: 64045 Rat Omim: 600443 Human SwissProt: P10575 Cow SwissProt: P35754 Human SwissProt: Q9QUH0 Mouse 谷氧還蛋白/巰基轉(zhuǎn)移酶抗體SwissProt: P12309 Pig SwissProt: P12864 Rabbit SwissProt: Q9ESH6 Rat Unigene: 28988 Human Unigene: 712696 Human Unigene: 25844 Mouse Unigene: 1484 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 谷氧還蛋白（Glutaredoxin，簡(jiǎn)稱為GRX）是一類小型的氧化還原酶，為大約只有一百個(gè)谷氧還蛋白/巰基轉(zhuǎn)移酶抗體氨基酸殘基的單鏈蛋白質(zhì)，并以谷胱甘肽作為輔因子。谷氧還蛋白被底物氧化，而非酶促地被谷胱甘肽還原。與可被硫氧還蛋白還原酶還原的硫氧還蛋白相反，并不存在特異性還原谷氧還蛋白的氧化還原酶。取而代之的是，谷氧還蛋白通過去氧化谷胱甘肽來被還原。被氧化的谷胱甘肽接下來被谷胱甘肽還原酶重生出來。NADPH、谷胱甘肽、谷胱甘肽還原酶和谷氧還蛋白這些組件組合在一起的氧化還原網(wǎng)絡(luò)構(gòu)成了谷胱甘肽系統(tǒng)。
產(chǎn)谷氧還蛋白/巰基轉(zhuǎn)移酶抗體品應(yīng)用：WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
研究領(lǐng)域：細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo)
儲(chǔ)存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
來源： Rabbit
外觀： Lyophilized or Liquid